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Merck KGaA
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24 mayo 2013
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An AIP (Cat. No. 189480) analog, in which Ala3 and Val10 are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC50 = 1 µM) and does not affect the activities of CaMK IV and PKA (IC50 > 100 µM).
| Información sobre producto | |||
|---|---|---|---|
| Peptide Sequence | H-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH | ||
| Form | White lyophilized solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | CAM Kinase-2 | ||
| Primary Target IC50 | 4.1 nM | ||
| Secondary target | PKC (IC50 = 1 µM) | ||
| Masa molar | 1602.9 | ||
| Hygrocopic | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥97% by HPLC | ||
| Solubilidad en agua | DMSO | ||
| Fórmula químico | C71H123N23O19 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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