190080
AY 9944
trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
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Merck KGaA
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64293 Darmstadt
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31 mayo 2012
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A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
| Información sobre producto | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | Δ7-sterol reductase | ||
| Primary Target IC50 | 13 nM | ||
| Hygrocopic | Si | ||
| Packaged under inert gas | Si | ||
| Cell permeable | Si | ||
| Purity | ≥95% by HPLC | ||
| Fórmula químico | C22H28Cl2N2 • 2HCl | ||
| RTECS | GU7025000 | ||
| Número CAS | 366-93-8 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
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