194975
B-Cell Immunosuppressant
N-[5-(Trifluoromethyl)pyridin-2-yl]quinole-8-carboxamide
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
loading
A cell-permeable quinolinecarboxamide that acts as a potent and highly selective B-cell immunosuppressant with a 75-fold selectivity for B- over T-cells and no general cytotoxicity. Does not affect DHO- and IMP-dehydrogenases, or the kinase activities of EGFR, PDGFR, Cdk2, and Src (IC50 > 30 µM). Shown to effectively block TI (T-cell signal independent) Ab production in vivo (ED50 ≤ 3 mg/kg/day, administered subcutaneously or orally in mice). It is ~100-fold superior to Leflunomide (0.3 mg/kg/day v.s. 50mg/kg/day, respectively) in suppressing Ab-mediated xenograft rejection in a mouse xenotransplantation model.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Molar mass | 317.3 | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C16H10F3N3O | ||
| CAS number | 237067-55-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |
||
