For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL↓DA-). Useful for high throughput screening of β-secretase inhibitors.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY) | ||
| Form | Lyophilized solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 2120.3 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Excitation max. | ~430 nm | ||
| Emission max. | ~520 nm | ||
| Solubility | DMSO | ||
| Chemical formula | C89H122N24O31S3 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
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