For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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An internally quenched fluorogenic peptide substrate designed from wild-type β-APP (β-amyloid precursor protein) sequence that selectively detects BACE1 (β-secretase 1), BACE2, and cathepsin D. Cleavage occurs between Met-Asp residues, which results in fluorescence enhancement. Also useful for screening of inhibitors for BACE1, BACE2, and cathepsin D.
| Product information | |||
|---|---|---|---|
| Peptide Sequence |
Abz-Val-Lys-Met~Asp-Ala-Glu-EDDnp Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine |
||
| Form | Lyophilized yellow solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 1019.1 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C43H62N12O15S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Blue Ice Only
Standard Handling |
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