For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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An internally quenched fluorogenic peptide substrate designed from Swedish mutated β-APP (β-amyloid precursor protein) sequence that specifically detects the activity of BACE1 (β-secretase 1) and BACE2, but not that of cathepsin-D, ADAM-10, TACE, PS1, or PS2. Cleavage occurs between Leu-Asp residues, which results in fluorescence enhancement. Also useful for screening of inhibitors for BACE1 & BACE2.
| Product information | |||
|---|---|---|---|
| Peptide Sequence |
Abz-Val-Asn-Leu~Asp-Ala-Glu-EDDnp Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine |
||
| Form | Lyophilized yellow solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 987.0 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C42H58N12O16 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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