208711
Ca2+/Calmodulin Kinase II Inhibitor 281-309
CaM Kinase II Inhibitor 281-309, MHRQETVDCLKKFNARRKLKGAILTTMLA-OH
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Merck KGaA
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64293 Darmstadt
Germany
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25 mayo 2013
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A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC50 = 80 nM) by blocking Ca2+/calmodulin activation and enzyme active site (IC50 = 2 µM).
| Información sobre producto | |||
|---|---|---|---|
| Peptide Sequence | H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH | ||
| Form | Lyophilized solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | cam Kinase-2 | ||
| Primary Target IC50 | 80nM | ||
| Secondary target | Ca2+/calmodulin (IC50 = 2 µM) | ||
| Masa molar | 3374.1 | ||
| Hygrocopic | Si | ||
| Purity | ≥97% by HPLC | ||
| Sold on the basis of peptide content | Si | ||
| Solubilidad en agua | H2O | ||
| Fórmula químico | C146H254N46O39S3 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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