218714
Casein Kinase II Inhibitor IV
5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid, IQA
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Merck KGaA
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31 May 2012
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A cell-permeable indoloquinazolinone compound that acts as a potent and selective CK2 inhibitor (IC50 = 390 nM with 100 µM ATP) in an ATP- and GTP-competitive manner (Ki = 0.17 and 0.21 µM, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 µM) and 48 commonly studied protein kinases (IC50 ≥10 µM with 100 µM ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC50 = 8 and <1 µM, respectively, with 100 µM ATP).
| Product information | |||
|---|---|---|---|
| Form | Light yellow solid | ||
| Molar mass | 292.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C17H12N2O3 | ||
| CAS number | 391670-48-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-24/25 Do not breathe dust. Avoid contact with skin and eyes. |
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