218717
Casein Kinase II Inhibitor V, Quinalizarin
1,2,5,8-Tetrahydroxy-9,10-anthraquinone
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A cell-permeable hydroxylated anthraquinone compound that acts as a potent (IC50 = 110 nM), highly selective (IC50 >1µM against CK1 and 83 other kinases), and ATP-competitive (Ki = 50 nM) CK2 inhibitor with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against DYRK1a, PIM1/3, and HIPK2. Quinalizarin is about 4.3- and 1.9-fold more effective than TBB, respectively, in cellular CK2 activity inhibition and in apoptosis induction in Jurkat cell cultures.
| Product information | |||
|---|---|---|---|
| Form | Dark red solid | ||
| Molar mass | 272.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C14H8O6 | ||
| CAS number | 81-61-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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