218718
Casein Kinase II Inhibitor VI, TMCB
ERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.
| Product information | |||
|---|---|---|---|
| Form | White powder | ||
| Molar mass | 534.8 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C11H9Br4N3O2 | ||
| CAS number | 905105-89-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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