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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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Cathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag® sequence.
Note: 1 mU = 1 milliunit.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 500 mM NaCl, 200 mM sodium acetate, 25 mM Tris-HCl, 10 mM trehalose, 5 mM DTT, 5 mM EDTA, 50% glycerol, pH 4.0. | ||
| Molar mass | 27000 | ||
| Avoid freeze/thaw | Yes | ||
| Specific activity | ≥900 mU/mg protein | ||
| Unit definition | One unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5. | ||
| Purity | ≥95% by SDS-PAGE | ||
| EC number | 3.4.22.38 | ||
| CAS number | 94716-09-3 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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