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31 May 2012
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A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~ 100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells.
| Product information | |||
|---|---|---|---|
| Form | Tan solid | ||
| Molar mass | 234.3 | ||
| Protect from Light | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C12H14N2OS | ||
| CAS number | 493028-20-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 24/25 Avoid contact with skin and eyes. |
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