215921
Chlorpromazine, Hydrochloride
2-Chloro-10-[3′-(dimethylamino)propyl]phenothiazine, HCl
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
| Product information | |||
|---|---|---|---|
| Form | Off-white crystalline solid | ||
| Primary Target | calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase | ||
| Molar mass | 355.3 | ||
| Hygrocopic | Yes | ||
| Purity | ≥99% by titration | ||
| Contaminants | Heavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05% | ||
| Solubility | MeOH or H2O | ||
| Chemical formula | C17H19ClN2S · HCl | ||
| RTECS | SO1750000 | ||
| CAS number | 69-09-0 | ||
| Merck USA index | 14, 2185 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Safety information | |||
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| S Phrase |
S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 25-26-36/37/38 Toxic if swallowed. Very toxic by inhalation. Irritating to eyes, respiratory system and skin. |
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