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Merck KGaA
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Germany
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31 May 2012
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Native, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In PBS, pH 7.4, sterile-filtered through a 0.22 µm filter. | ||
| Preservative | None | ||
| Avoid freeze/thaw | Yes | ||
| Biological activity | ≥80% of C1-esterase inhibitor will bind activated C1s. | ||
| Purity | ≥90% by SDS-PAGE | ||
| Contaminants | IgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin: ≤trace amounts | ||
| Source | Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
||
