203890
CRAC Channel Inhibitor, BTP2
[N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide]
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A cell-permeable analog of 3,5-bis(trifluoromethyl)pyrazole (BTP) that specifically inhibits CRAC-mediated calcium influx in T-cells with an IC50 about 10 nM and displays ~31-fold greater selectivity over VOC. Blocks the calcium-induced activation and translocation of nuclear factor of activated T-cells (NFAT). Does not affect the activation of NF-κB and AP-1. Potently inhibits cytokine production (IC50 = 1.7 µM for IL-2) and PBMC proliferation (IC50 = 190 nM).
| Product information | |||
|---|---|---|---|
| Form | Solid | ||
| Molar mass | 421.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C15H9F6N5OS | ||
| CAS number | 223499-30-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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