239804
Cyclopamine-KAAD
3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
31 Mai 2012
wird geladen
A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis.
| Produktinformationen | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Primary Target | Hh signaling in Shh-light2 assay | ||
| Primary Target IC50 | 20 nM | ||
| Secondary target | in P2Ptch-/-cells (IC50 = 50 nM) | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Cell permeable | Ja | ||
| Purity | ≥70% by HPLC (sum of two isomers) | ||
| Chemische Formel | C44H63N3O4 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Harmful |
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| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-36/37 |
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| R-Satz |
R: 20/21/22 |
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