239777
Cyclophilin A, Human, Recombinant, E. coli
Peptidylproline cis-trans-Isomerase
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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Recombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomerization of X-Pro peptide bonds. Binds to proteins and acts as a chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. No. 239835). This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 20 mM Tris-HCl, pH 7.8. | ||
| Molar mass | 18000 | ||
| Purity | ≥90% by SDS-PAGE | ||
| EC number | 5.2.1.8 | ||
| CAS number | 95076-93-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Blue Ice Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 24/25-36 Avoid contact with skin and eyes. Wear suitable protective clothing. |
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