For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
loading
Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells.
| Product information | |||
|---|---|---|---|
| Form | White to off-white solid | ||
| Primary Target | NOS induced by interlukin-1-α | ||
| Molar mass | 1202.6 | ||
| Purity | ≥97% (dry basis) | ||
| Solubility | DMSO, EtOH, or MeOH | ||
| Chemical formula | C62H111N11O12 | ||
| RTECS | GZ4120000 | ||
| CAS number | 59865-13-3 | ||
| Merck USA index | 14, 2752 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-24/25-36/37 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing and gloves. |
||
| R Phrase |
R: 40 Limited evidence of a carcinogenic effect. |
||
