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138000  D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem

4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8

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24 April 2014

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Product number Qty/Pk Quantity Price
138000-50MG  50 mg  loading
Prices are subject to change without notice.
A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
Product information
Form Beige solid
Molar mass 167.2
Protect from Light Yes
Packaged under inert gas Yes
Purity ≥97% by HPLC
Solubility DMSO or 5% NaOH
Chemical formula C7H5NO2S
CAS number 39793-31-2
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful
Safety information
S Phrase S: 26-36/37/39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
R Phrase R: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


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