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31 May 2012
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An antitumor agent and protein kinase C (PKC) inhibitor. When exposed to UV light, DECA covalently binds to and irreversibly inhibits PKCα and PKCβ (IC50 = 7-18 µM). A potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel (IC50 = 1.1 µM). A blocker of ganglionic transmission (EC50 = 2 µM). Selectively accumulates within the mitochondria of carcinoma cells and disrupts energy production.
| Product information | |||
|---|---|---|---|
| Form | White powder with a dark yellow cast | ||
| Primary Target | PKCα, PKCβ | ||
| Primary Target IC50 | 7-18 µM | ||
| Secondary target | Ca2+-activated K+ channel (IC50 = 1.1 µM) | ||
| Molar mass | 527.6 | ||
| Purity | ≥95% by titration | ||
| Solubility | DMSO; slightly soluble in H2O | ||
| Chemical formula | C30H40Cl2N4 | ||
| RTECS | VA0700000 | ||
| CAS number | 522-51-0 | ||
| Merck USA index | 14, 2913 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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