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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
01 Juni 2012
wird geladen
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
| Produktinformationen | |||
|---|---|---|---|
| Form | Beige solid | ||
| Primary Target | elF-2α | ||
| Secondary target | Hsv rep. in vitro cells (IC50 = 3 µM) | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Cell permeable | Ja | ||
| Purity | ≥90% by HPLC | ||
| Chemische Formel | C21H17Cl3N4OS | ||
| CAS-Nummer | 304475-63-6 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
||
