324762
Endopeptidase, Neutral, Porcine Kidney
CD10, Common Acute Lymphocytic Antigen, Endopeptidase-24.11, Enkephalinase, Microvillus Proteinase, Neprilysin
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Merck KGaA
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01 June 2012
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Native, neutral endopeptidase from porcine kidney. A cell surface, zinc containing metallopeptidase that is abundant in the brush border membrane of the kidney proximal tubules. Also present in brain, endothelial cells, liver, and lung. Peptidase activity is specifically directed toward the cleavage on the amino side of hydrophobic residues. Contains an arginine in the active site that can interact with the C-terminal carboxylate of substrates.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized | ||
| Formulation | Lyophilized from 150 mM NaCl, 25 mM Tris-HCl, 5 mM CaCl2, TRITON® X-100 Detergent, pH 7.4. | ||
| Molar mass | 90000 | ||
| Specific activity | ≥850 units/mg protein | ||
| Unit definition | One unit of enzyme will liberate 1.0 µmol pNA per min from Glutaryl-(Ala)2-Phe-pNA at 25°C, pH 7.4. | ||
| Purity | ≥95% by HPLC | ||
| Solubility | Physiological Buffers | ||
| EC number | 3.4.24.11 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Canadian export regulations | Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada. | ||
