341291
Fas/FasL Antagonist, Kp7-6
H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
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An exocyclic cystine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling pathways. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H2N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO2H, Cyclic [disulfide bond between Cys-Cys] | ||
| Form | White lyophilized powder | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | specifically antagonizes Fas/FasL-mediated cellular apoptotic signals | ||
| Molar mass | 1077.2 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C48H56N10O15S2 | ||
| Declaration | Sold under license of U.S. Patent 7,288,519. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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