344079
Flurbiprofen
(±)-2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic Acid, U-27182
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
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A mixture of S(+) and R(–) enantiomers. A cell-permeable, non-steroidal anti-inflammatory agent that acts as a potent inhibitor of cyclooxygenase (IC50 = 5 nM for LPS-induced COX in human peripheral blood cells). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Suppresses iNOS expression in RAW 264.7 macrophages. Reduces microglial activation and β-amyloid deposit in APP+PS1 transgenic mice.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | COX, LPS induced | ||
| Primary Target IC50 | 5 nM | ||
| Molar mass | 244.3 | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by titration | ||
| Solubility | DMSO | ||
| Chemical formula | C15H13FO2 | ||
| RTECS | DU8341000 | ||
| CAS number | 5104-49-4 | ||
| Merck USA index | 14, 4199 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Toxic & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 25 Toxic if swallowed. |
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