344150
FPT Inhibitor I
(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic Acid, 3Na
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
24 May 2012
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Potent and highly selective inhibitor of farnesyltransferase (FTase; IC50 = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | FTase | ||
| Primary Target IC50 | 83 nM | ||
| Secondary target | geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC50 = 26 µM and 47 µM for GGTase I and II, respectively) | ||
| Molar mass | 467.4 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥85% by NMR | ||
| Solubility | H2O | ||
| Chemical formula | C19H29NO6P · 3Na | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
