344152
FPT Inhibitor II
(E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na
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Merck KGaA
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01 June 2012
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A cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | FTase | ||
| Primary Target IC50 | 75 nM | ||
| Molar mass | 457.4 | ||
| Hygrocopic | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C17H28NO5P • 2Na • 3H2O | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
