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01 June 2012
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A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase; IC50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Exhibits carcinogenic properties.
| Product information | |||
|---|---|---|---|
| Form | White to beige powder | ||
| Primary Target | ceramide synthase | ||
| Primary Target IC50 | 100 nM | ||
| Secondary target | sphingomyelin biosynthesis in neuronal cells | ||
| Molar mass | 721.8 | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by TLC | ||
| Solubility | MeOH | ||
| Chemical formula | C34H59NO15 | ||
| RTECS | TZ8350000 | ||
| CAS number | 116355-83-0 | ||
| Merck USA index | 14, 4289 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-26-36/37/39 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. |
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| R Phrase |
R: 40 Limited evidence of a carcinogenic effect. |
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