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Merck KGaA
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64293 Darmstadt
Germany
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01 June 2012
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An internally quenched fluorogenic peptide substrate containing the C-terminal β-APP (amyloid β-peptide precursor protein) amino acid sequence that is cleaved by γ-secretase. Shown to be sensitive and useful for assaying γ-secretase activity. The proteolysis at the Aβ40-, Aβ42-, and Aβ43-generating cleavage sites results in enhanced fluorescence.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | NMA-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(DNP)-D-Arg-D-Arg-D-Arg-NH2 | ||
| Form | Yellow Lyophilized | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 1609.9 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or 5% Acetic Acid | ||
| Chemical formula | C70H116N26O18 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
