400090
IC261
3-[(2,4,6-Trimethoxyphenyl)methylidenyl]-indolin-2-one, SU5607
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
31 May 2012
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A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC50 = 0.7-1.3 µM) and CK1ε (IC50 = 0.6-1.4 µM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 µM). The inhibition is competitive with respect to ATP. Only weakly inhibits PKA, p34cdc2, and p55fyn (IC50s > 100 µM). At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | CK1d | ||
| Primary Target IC50 | 0.7-1.3 µM | ||
| Secondary target | CK1e (IC50 = 0.6-1.4 µM), CK1a1 (IC50 = 11-21 µM), PKA, p34cdc2, and p55fyn (IC50 > 100 µM) | ||
| Molar mass | 311.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥95% by HPLC (sum of two isomers) | ||
| Solubility | DMSO | ||
| Chemical formula | C18H17NO4 | ||
| CAS number | 186611-52-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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