For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
loading
A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). The solid form of this compound (Cat. No. 573102) is also available.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO. | ||
| Molar mass | 365.4 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Chemical formula | C16H15NO7S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Dry Ice Only
Irritant |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
||
| R Phrase |
R: 36/38 Irritating to eyes and skin. |
||
