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19 junio 2013
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A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
| Información sobre producto | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | JAK2 autophosphorylation | ||
| Masa molar | 557.5 | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Cell permeable | Si | ||
| Purity | ≥ 97% by GC | ||
| Solubilidad en agua | DMSO | ||
| Fórmula químico | C6H6Br6 | ||
| Número CAS | 1837-91-8 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
