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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
22 Mai 2013
wird geladen
A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM).
| Produktinformationen | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | topoisomerase I-catalyzed DNA religation in HL-60 cells | ||
| Secondary target | Monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50 < 15 µM) | ||
| Molare Masse | 286.2 | ||
| Protect from Light | Ja | ||
| Packaged under inert gas | Ja | ||
| Cell permeable | Ja | ||
| Purity | ≥97% by HPLC | ||
| Löslichkeit in Wasser | DMSO | ||
| Chemische Formel | C15H10O6 | ||
| RTECS | LK9275200 | ||
| CAS-Nummer | 520-18-3 | ||
| Merck USA index | 14, 5274 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-26-36 |
||
| R-Satz |
R: 36/37/38-40 |
||
