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01 June 2012
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An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.
| Product information | |||
|---|---|---|---|
| Form | Yellow to brown solid | ||
| Primary Target | FTAse | ||
| Primary Target IC50 | 5 mM | ||
| Secondary target | geranylgeranyltransferase I (GGTase I; IC50 = 180 mM), farnesylpyrophosphate (FPP; Ki = 1.2 mM) | ||
| Molar mass | 550.7 | ||
| Protect from Light | Yes | ||
| Purity | ≥96% by HPLC | ||
| Solubility | DMSO, MeOH or CHCl3 | ||
| Chemical formula | C31H38N2O7 | ||
| CAS number | 52665-74-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
