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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
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01 Juni 2012
wird geladen
Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.
| Produktinformationen | |||
|---|---|---|---|
| Form | Lyophilized pale-yellow solid | ||
| Primary Target | PP1 | ||
| Primary Target IC50 | 1.7 nM | ||
| Secondary target | PP2A (IC50 = 40 pM) | ||
| Purity | ≥95% by HPLC | ||
| Chemische Formel | C49H74N10O12 | ||
| RTECS | GT2810000 | ||
| CAS-Nummer | 101043-37-2 | ||
| Declaration | Not available for sale outside of the United States. | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
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Achtung Gefahrgut:Aufgrund der Natur des in dieser Lieferung enthaltenen Gefahrgutes können zusätzliche Versandkosten für Ihren Auftrag entstehen. Bestimmte Größen können ggf. von den Versandzuschlägen für Gefahrgüter ausgenommen sein. Bitte kontaktieren Sie Ihr lokales Verkaufsbüro für weitere Informationen bzgl. dieser Gebühren. |
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| Lagerkategorie | -20°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic |
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| End use certificate | To purchase this product, the completion of a "Select Agent Declaration" and/or "End-Use Certificate" is required. Once your sales order is placed, our Regulatory Specialist will be contacting the end-user of this product to complete the required form(s). Please ensure to provide the customer service representative with the end-user's name, telephone number, fax number and e-mail address to prevent delivery delays. (Note: the completed form must be returned within five (5) business days from receipt and will be valid for one year from the date of signing.) | ||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 26-36/37/39-45 |
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| R-Satz |
R: 26/27/28-36/37/38-43 |
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