475843
Minocycline, Hydrochloride
7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefon: +49 6151 72-0
Fax: +49 6151 72 2000
01 Juni 2012
wird geladen
Semi-synthetic tetracycline derivative effective against tetracycline-resistant staphylococci. A matrix metalloproteinase (MMP) inhibitor shown to inhibit tumor-induced angiogenesis. Inhibits stromelysin (MMP-3; IC50 = 290 µM) but does not inhibit other MMPs such as fibroblast collagenase or gelatinase. Potently inhibits PARP-1 (Ki = 13.4 nM) in a NAD+ - competitive manner. Exhibits anti-inflammatory effects and suppresses T cell proliferation.
| Produktinformationen | |||
|---|---|---|---|
| Form | Dark yellow solid | ||
| Purity | ≥98% by TLC | ||
| Chemische Formel | C23H27N3O7 · HCl | ||
| RTECS | QI7630500 | ||
| CAS-Nummer | 13614-98-7 | ||
| Merck USA index | 14, 6202 | ||
| Lager- und Versandinformationen | |||
|---|---|---|---|
| Lagerkategorie | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
| Sicherheitshinweise | |||
|---|---|---|---|
| S-Satz |
S: 22-45-36 |
||
| R-Satz |
R: 33-36/37/38-63-64 |
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