480743
Neuronal Differentiation Inducer III
N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
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01 June 2012
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A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 234.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C11H10N2O2S | ||
| CAS number | 832115-62-5 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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