482251
NIPP-1, His•Tag®, Bovine Thymus, Recombinant, E. coli
Nuclear Inhibitor of Protein Phosphatase-1
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
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Recombinant, bovine NIPP-1 fused to a His•Tag® sequence and expressed in E. coli. Potent and specific inhibitor of protein phosphatase 1 (PP1; Ki = 1-10 pM) that can be used to distinguish PP1 from other major serine/threonine protein phosphatases including PP2A, PP2B, and PP2C. Also an ideal substrate for protein kinase A and casein kinase II. Thought to be involved in the targeting of PP1 to RNA-associated substrates and may also be involved in the dephosphorylation of transcription factors like CREB and the tumor suppressor Rb.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 500 mM NaCl, 20 mM Tris, 500 µM benzamidine, 500 µM PMSF, 5 µM leupeptin, pH 7.5. | ||
| Primary Target | PP1 | ||
| Primary Target Ki | 1-10 pM | ||
| Molar mass | 38500 | ||
| Avoid freeze/thaw | Yes | ||
| Purity | ≥90% by SDS-PAGE | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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