539654
PKCβ Inhibitor
3-(1-(3-Imidazol-1-ylpropyl)-1H-indol-3-yl)-4-anilino-1H-pyrrole-2,5-dione
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
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Fax: +49 6151 72 2000
01 June 2012
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An anilino-monoindolylmaleimide compound that acts as a potent, cell-permeable, reversible, and ATP-competitive inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI) and displays greater selectivity over PKCα, γ,& ε (IC50 = 331 nM, > 1 µM, and 2.8 µM, respectively).
| Product information | |||
|---|---|---|---|
| Form | Orange solid | ||
| Primary Target | PKCβII, βI | ||
| Primary Target IC50 | 5 nM, 21 nM | ||
| Secondary target | PKCα, γ, ε (IC50 = 331 nM, > 1 µM, 2.8 µM, respectively) | ||
| Molar mass | 411.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C24H21N5O2 | ||
| CAS number | 257879-35-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |
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