528284
Polo-like Kinase Inhibitor III
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)-benzyl)oxy)thiophene-2-carboxamide, Plk Inhibitor III
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01 junio 2012
cargando
A cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against polo-like kinases (K i against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 µM) over normal human diploid fibroblasts (IC50 = 6.14 µM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.
| Información sobre producto | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Protect from Light | Si | ||
| Packaged under inert gas | Si | ||
| Purity | ≥97% by HPLC | ||
| Fórmula químico | C22H18F3N3O4S | ||
| Número CAS | 660868-91-7 | ||
| Almacenar y enviar información | |||
|---|---|---|---|
| Categoría de alamacenamiento | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Información de seguridad | |||
|---|---|---|---|
| Frase S |
S: 26-36/37-45 |
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| Frase R |
R: 36/37/38 |
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