516559
PPARα, Human, Recombinant, E. coli
Peroxisome Proliferator-Activated Receptor, α-isotype
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
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Recombinant, human PPARα expressed in E. coli. Belongs to the family of peroxisome proliferator-activated receptors (PPARs), the nuclear hormone receptors that are activated by fatty acids and derivatives. PPARα is expressed most in brown adipose tissue and liver, and to some extent in the kidney, heart, and skeletal muscle. The target genes of PPARα are a relatively homogeneous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes, and mitochondria) and lipoprotein assembly and transport.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 100 mM KCl, 20 mM Tris-HCl, 0.2 mM EDTA, 1 mM DTT, 20% glycerol, pH 8.0. | ||
| Molar mass | 52000 | ||
| Avoid freeze/thaw | Yes | ||
| Unit definition | One unit is equal to 1 ng of purified protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay. | ||
| Purity | ≥95% by SDS-PAGE | ||
| Contaminants | DNase, RNase, and protease activity: none detected | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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