Reagents for DPP IV Research

Dipeptidyl peptidase IV (DPP IV), a widely distributed, multifunctional transmembrane serine protease, has attracted considerable interest in recent times. It modulates the activity of several peptide hormones by cleaving Xaa-Pro or Xaa-Ala from their NH₂-terminal. DPP IV functions as a dimer and each monomeric subunit has an α/β hydrolase domain and an eight-bladed β-propeller domain. Both these domains participate in inhibitor binding at the active site. Of considerable interest is the cleavage of glucagon-like peptide-1 (GLP-1) by DPP IV.

GLP-1 is shown to be important in maintaining glucose homeostasis. It blocks glucagon secretion, delays gastric emptying, and stimulates insulin biosynthesis. GLP-1 has been under consideration as an alternate treatment for type II diabetes. However, its short half-life (<1 min) severely limits its use as a treatment option. To overcome this difficulty, inhibition DPP IV has been proposed as a viable option and DPP IV inhibitors are shown to improve glucose tolerance in animal models of type II diabetes.

Assay Kits 

Producto	Núm. prod.
InnoZyme™ DPP IV Activity Assay Kit	CBA097
InnoZyme™ DPP IV Immunocapture Activity Assay	CBA085

Antibody 

Enzymes

Producto	Núm. prod.
Dipeptidyl Peptidase IV (CD26), Porcine Kidney	317640
Dipeptidylpeptidase IV, His•Tag®, Human, Recombinant, S. frugiperda	317639
Dipeptidylpeptidase IV, Human Placenta	317630

Substrate

Producto	Núm. prod.
Dipeptidylpeptidase IV Substrate I, Fluorogenic	125510

Inhibitor

Producto	Núm. prod.
Dipeptidylpeptidase IV Inhibitor I	416200