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01 June 2012
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A cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 µM. The first organic molecule that has been demonstrated to reverse the cellular differentiation process. Acts as a selective A3 adenosine receptor antagonist (Ki = 660 nM, >10 µM, and >10 µM for hA3, hA1, and hA2A, respectively. Functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). Also acts as an ATP-competitive, reversible and selective inhibitor of Aurora Kinases A, B and C (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel. Shown to be a potent, selective, and ATP-competitive inhibitor of MPS1 (IC50 = 2.8 nM, full-length enzyme).
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 393.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C21H27N7O | ||
| CAS number | 656820-32-5 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
||
