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559300  Safingol

L-threo-Dihydrosphingosine

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18 April 2014

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Product number Qty/Pk Quantity Price
559300-1MG  1 mg  loading
Prices are subject to change without notice.
A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 µM and 31 µM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 µM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.
Product information
Form White solid
Primary Target enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC
Primary Target IC50 37.5 mM and 31 mM, respectively
Secondary target human PKCa, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 mM)
Molar mass 301.5
Purity ≥98% by TLC
Solubility DMSO, EtOH, or MeOH
Chemical formula C18H39NO2
CAS number 15639-50-6
Store and ship information
Storage -20°C
Ship Ambient Temperature Only
Irritant
Safety information
S Phrase S: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
R Phrase R: 36/37/38

Irritating to eyes, respiratory system and skin.
Safingol, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014


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