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25 May 2013
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A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 µM and 31 µM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 µM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC | ||
| Primary Target IC50 | 37.5 mM and 31 mM, respectively | ||
| Secondary target | human PKCa, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 mM) | ||
| Molar mass | 301.5 | ||
| Purity | ≥98% by TLC | ||
| Solubility | DMSO, EtOH, or MeOH | ||
| Chemical formula | C18H39NO2 | ||
| CAS number | 15639-50-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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