344300
sFRP-1 Inhibitor
N-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
01 June 2012
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A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
| Product information | |||
|---|---|---|---|
| Form | Clear oil | ||
| Molar mass | 410.6 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C19H26N2O4S2 | ||
| CAS number | 915754-88-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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