Information
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573092  STAT3 Inhibitor Peptide II, ErbB2-Selective, Cell-Permeable

H-YGRKKRRQR-G-FCDGFYACYKDV-PpYL-OH, Cyclic, P3-AHNP-STAT3BP

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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000

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01 June 2012

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This product has been discontinued.





The SH2 domain-binding motif- (Cat. No. 573095) derived STAT3 inhibiting sequence, PpYL (STAT3BP), is conjugated with a cell-permeant carrier sequence P3-AHNP (Cat. No. 573094), to allow its preferential delivery to ErbB2 high-expressing cells for STAT3 inhibition. P3-AHNP-STAT3BP has been shown to selectively inhibit the growth of ErbB2-overexpressing cancer cells both in vitro and in vivo.
Product information
Peptide Sequence H2N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Gly-Phe-Cys-Asp-Gly-Phe-Tyr-Ala-Cys-Tyr-Lys-Asp-Val-Pro-Tyr(PO3H2)-Leu-CO2H, Cyclic
Form Lyophilized
Formulation Supplied as a trifluoroacetate salt
Molar mass 3168.5
Protect from Light Yes
Hygrocopic Yes
Packaged under inert gas Yes
Purity ≥97% by HPLC
Solubility H2O
Chemical formula C140H208N41O38PS2
Declaration Sold under license of U.S. Patent 7,179,785.
Store and ship information
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling

© Merck KGaA, Darmstadt, Germany, 2012


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