Linkers & Activators

For the transformation of a primary amine to a sulfhydryl group in drugs and therapeutic proteins.

For conjugation with monoclonal antibodies, proteins, peptides and herbicides.

As a hetero-bifunctional crosslinker for proteins with Dithionitrobenzoic acid (DTNB).

Immobilisation of colloidal particles with a sulfhydryl-maleimide bond.

References:

• Traut et al, Biochemistry, 12, (1973), 3266,
• Alam et al., Indian J Exp. Biology, 40, (2002), 477.
• Wang et al., J Nucl. Med., 33, (1992), 570.
• Suwa et al., Anticancer Resear.,19, (1999), 4161.
• Phaneuf et al., Biomaterials, 18,(1997), 755.

C4H8ClNS
MW  137.63
CAS No.: 4781-83-3

• 2-Iminothiolane Hydrochloride
• Traut’s Reagent
• 2(3H)-Thiophenimine, dihydro-, hydrochloride

Traut’s Reagent is a white to off-white, crystalline substance.

• Soluble in water (e.g. 1 g/ 1 ml at 20-22°C), methanol, ethanol, DMSO.
• Low solubility in acetonitrile, ethyl acetate, DMF.
• Insoluble in diethyl ether, methyl tert. butyl ether.

• Traut et al, Biochemistry, 12, (1973), 3266
• King et al., Biochemistry, 17, (1978), 1499

Appearance:

The product is sensitive to moisture and has to be stored under dry conditions. The recommended storage condition is 2 - 8°C. To date no degradation under these storage conditions have been observed.

The material is packed in amber glass bottles or a polyethylene bag under inert atmosphere. The packaged material is put into an aluminum-polyethylene composite foil to protect it from humidity-

For full safety information, necessary precautions and proper handling, please refer to the respective Material Safety Data Sheet (MSDS).