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474790  MG-132 - CAS 133407-82-6 - Calbiochem

Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI

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23 April 2014

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474790-10MG  10 mg 
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474790-1MG  1 mg 
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474790-20MG  20 mg 
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474790-5MG  5 mg 
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A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available.
Product information
Peptide Sequence Z-Leu-Leu-Leu-CHO
Form White solid
Primary Target proteasome
Primary Target Ki 4 nM
Secondary target NF-κB (IC50 = 3 µM)
Molar mass 475.6
Cell permeable Yes
Reversible Yes
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C26H41N3O5
CAS number 133407-82-6
Store and ship information
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
MG-132 - CAS 133407-82-6 - Calbiochem, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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