197228 Sigma-AldrichBCRP Inhibitor IV, YHO-13351 - Calbiochem
The BCRP Inhibitor IV, YHO-13351 controls the biological activity of BCRP.
More>> The BCRP Inhibitor IV, YHO-13351 controls the biological activity of BCRP. Less<<BCRP Inhibitor IV, YHO-13351 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Diethylaminoacetic acid, 1-(5-((Z)-2-cyano-2- (3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate
Recommended Products
Overview
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Key Spec Table
| Empirical Formula |
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| C₂₆H₃₃N₃O₄S • CH₃SO₃H |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 197228-25MG |
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Glass bottle | 25 mg |
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| Description | |
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| Overview | An in vivo bioavailable (~87%; t1/2 < 5 mins. during p.o. and i.v. administration) and highly water soluble ( >100 mg/ml) diethylaminoacetate prodrug of YHO-13177 (Cat. No. 197227) that reverses BCRP-mediated irinotecan resistance in P388/BCRP and HCT116/BCRP xenograft mouse models, and suppresses tumor growth and significantly enhances the survival (100 or 200 mg/kg, i.p.). |
| Catalogue Number | 197228 |
| Brand Family | Calbiochem® |
| Synonyms | Diethylaminoacetic acid, 1-(5-((Z)-2-cyano-2- (3,4-dimethoxyphenyl)vinyl)thiophen-2-yl)piperidin-4-yl ester, Methanesulfonate |
| References | |
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| References | Yamazaki, R., et al. 2011. Mol. Cancer Ther. 10, 1252. |
| Product Information | |
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| Form | Yellow solid |
| Hill Formula | C₂₆H₃₃N₃O₄S • CH₃SO₃H |
| Chemical formula | C₂₆H₃₃N₃O₄S • CH₃SO₃H |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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Documentation
BCRP Inhibitor IV, YHO-13351 - Calbiochem SDS
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BCRP Inhibitor IV, YHO-13351 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 197228 |
References
| Reference overview |
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| Yamazaki, R., et al. 2011. Mol. Cancer Ther. 10, 1252. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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