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Merck

444250

MMP Inhibitor I

The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP Inhibitor I, FN-439

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About This Item

Empirical Formula (Hill Notation):
C23H34N6O6
Molecular Weight:
490.55
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

MMP Inhibitor I, The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥95% (HPLC)

form

solid

potency

1 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-1, MMP-8
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.

Other Notes

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Jörg Weiske et al.
Methods in molecular biology (Clifton, N.J.), 289, 175-192 (2004-10-27)
In epidermal cells desmosomes represent major sites of basolateral cell-cell contacts that play an important role for epidermal homeostasis. Excess or damaged cells are often removed by apoptosis. To release apoptotic cells from the tissue, intercellular contacts have to be

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