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Merck

GF309

NT-4 Protein, Human Recombinant Animal Free

The Neurotrophin-4 protein (or NT-4 protein), also known as NT-5 protein, is a member of the NGF family of neuronal & epithelial growth factors.

Synonym(s):

NT4, Neurotrophin 4, Neurotrophin 4/5, NT4/5

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
eCl@ss:
32160405

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Product Name

NT-4 Protein, Human Recombinant Animal Free, The Neurotrophin-4 protein (or NT-4 protein), also known as NT-5 protein, is a member of the NGF family of neuronal & epithelial growth factors.

assay

>98% (SDS-PAGE and HPLC)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

NCBI accession no.

NM_006179.3

UniProt accession no.

P34130

shipped in

dry ice

Quality Level

100

Related Categories

Analysis Note

Bioactivity assay: The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.

Biochem/physiol Actions

Cross Reactivty
Mouse, Rat

General description

Neurotrophin4 (NT4), also known as NT5, is a member of the NGF family of neuronal and epithelial growth factors. NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

Physical form

Recombinant animal free human NT-4 is manufactured using all non-animal reagents

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
GF30904053252691324

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